Reagents

Reagent Type Created Author Actions

Necdin-null mice

Mice with a gene-tergeted deletion of Necdin are available from the Jackson Laboratories.  See http://jaxmice.jax.org/strain/009089.html.  B6.129S1(Cg)-Ndntm2Stw/J,  Stock number 009089  Repository- Live

 

 

 
Model July 10, 2013 rwevrick

Magel2-null mice

Mice gene targeted for Magel2 are available from the Jackson Laboratories. See http://jaxmice.jax.org/strain/009062.html.  Strain Name: C57BL/6-Magel2tm1Stw/J, Stock Number: 009062, Availability: Cryopreserved - Ready for recovery

Model July 10, 2013 rwevrick

Expression constructs for necdin and Magel2

A variety of plasmids are available in which either necdin or Magel2 cDNA is cloned into  vectors for expression in yeast, bacteria, or mammalian cells. Contact RachelWevrick@ualberta.ca for information.

Vector July 10, 2013 rwevrick

PWS-IC<del> mice

When females heterozygous for the PWS-ICdel mutation are bred with wildtype males, the resulting offspring are viable and fertile as adults. In contrast, paternal transmission of the PWS-ICdel mutation results in neonatal lethality between 1-7 days of age (failure to [...]

Model August 6, 2013 msasner

PWS-IC<flox6kb> mice

These PWS-ICflox6kb mice may be useful in generating conditional mutations for studying the role of Snrpn and the temporal and developmental requirements of the Prader-Willi imprinting center.

Mice homozygous for this PWS-ICflox6kb allele are viable and fertile, [...]

Model August 6, 2013 msasner

Nes-cre mice

When crossed to male mice carrying the PWS-IC<flox6kb> allele (see JAX Stock No.018395), Cre recombinase expression in brain precursors cells starting at E10.5 results in a growth retardation, but is not lethal.

For more information [...]

Model August 6, 2013 msasner

CMV-cre mice

When crossed to male mice carrying the PWS-IC<flox6kb> allele (see JAX Stock No. 018395), widespread Cre recombinase expression prior to implantation results in postnatal lethality.

For more information [...]

Model August 6, 2013 msasner
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